NEWEST | Polynucleotide Skin Booster Treatment Nexus Clinic KL
Improve skin hydration, elasticity, glow and overall skin quality with NEWEST in Malaysia. Nexus Clinic KL offers doctor-led NEWEST polynucleotide treatment for smoother, firmer and healthier-looking skin.
Your skin can start feeling different long before it looks obviously older. It gets drier. A bit thinner. Fine lines don't bounce back the way they used to. Makeup stops sitting smoothly on your face. The glow fades and the skin starts looking flat or tired, even on days when you've slept well and eaten properly. That's usually the point where your skincare routine stops being enough, not because you're using the wrong products, but because the problem is happening at a level products cannot reach. NEWEST works at that level.
Important Clinical Note
NEWEST is a PN-HPT injectable skin booster that supports fibroblast activity, collagen renewal, hydration and elasticity. It is enhanced with hyaluronic acid for stronger hydration and plumper skin texture. It is not a filler and does not change your facial structure.
Hydration + Regeneration
Natural glow • Long-lasting
NEWEST Treatment at a Glance
Everything you need to know about this polynucleotide skin booster
Treatment Type
PN-HPT polynucleotide skin booster with hyaluronic acid
Common Helps With
Hydration, elasticity, radiance, collagen support, regeneration
Session Time
20 to 45 minutes
Downtime
Low, mild temporary redness or swelling
Recommended Sessions
3 to 4 sessions
Results Duration
Up to 12 months
Common Areas
Face, neck, décolleté, under-eyes, hands
Suitable For
Dull skin, dehydration, reduced elasticity, early ageing
What Is NEWEST and How It Works
NEWEST is an injectable skin booster made by Mastelli, an Italian pharmaceutical company. It is not a filler, it does not add volume to your cheeks, it does not reshape your face, and it does not give you that heavy, overdone look that puts a lot of people off aesthetic treatments. What sets it apart from a basic skin booster is the formula. NEWEST combines three things that work together:
PN-HPT (Polynucleotide Highly Purified Technology)
This is the main ingredient and the reason NEWEST is categorised differently from a regular hydration injectable. Polynucleotides are DNA fragments extracted from Italian trout using Mastelli's patented purification process. The HPT process removes all proteins and contaminants, leaving only the active DNA chains. When these are injected into the skin, they signal your fibroblasts, which are the cells responsible for producing collagen and elastin, to become active again. Over time the skin starts rebuilding what it has been losing
Hyaluronic Acid
Unlike Plinest which uses pure polynucleotides, NEWEST adds non-cross-linked hyaluronic acid to the formula. HA draws and holds moisture in the skin. But the more interesting part is that clinical data shows combining HA with PN-HPT increases fibroblast-stimulating activity by 20 percent. They make each other more effective, not just in parallel but because of each other
Mannitol
An antioxidant that slows the breakdown of hyaluronic acid after injection, by around 30 percent according to clinical data. This means the treatment stays active in the skin longer, which matters a lot for the regeneration process to actually complete.
Clinical evidence supports the role of polynucleotides in skin regeneration. A 2024 review by Lee KWA et al. demonstrated that polynucleotides improve skin texture, enhance elasticity, stimulate collagen production, and support overall skin rejuvenation, aligning with their role in regenerative injectable skin treatments.
NEWEST restores skin hydration, elasticity, and radiance through polynucleotide regeneration. For patients with age-related volume loss in the midface, Sculptra Malaysia offers deeper collagen stimulation. Those with hollow under-eyes may also benefit from under eye filler Malaysia combined with NEWEST.
What NEWEST Helps Improve
At Nexus Clinic KL, NEWEST is used for patients whose concern is skin quality, not structure or volume. Here is what it genuinely helps with:
Dehydrated Skin
Malaysia's heat, humidity, UV exposure and air conditioning create a dehydration cycle that topical moisturisers cannot really break. The hyaluronic acid in NEWEST works from inside the dermis, which is where hydration actually needs to be restored for the skin to look and feel different.
Reduced Elasticity
When skin starts losing its bounce and firmness, that is elastin breaking down faster than the skin can replace it. NEWEST supports fibroblast activity which helps the skin rebuild that elastin over the course of treatment. It is not immediate but it is real.
Dull and Tired-Looking Skin
A lot of skin dullness comes from poor skin quality at the dermal level, not from the surface. When the skin has better hydration and stronger internal support, it reflects light differently. That is where the glow comes from and why patients notice it fairly early into the treatment course.
Early Ageing and Fine Lines
These are the fine lines caused by thinning skin and collagen loss, not deep-set folds. As collagen rebuilds over the treatment course, texture improves and these lines soften. It takes time but the change is coming from the right place.
Crepey or Fragile Skin
Skin that feels thin or papery, especially on the neck, under-eyes, décolletage and hands, responds well to polynucleotides because the repair mechanism targets the structural cause rather than just masking it. These are also areas where filler is not a useful option, which makes NEWEST particularly suited here.
Under-Eye Area
One of the more practical applications. The skin under the eyes is thin and delicate, and NEWEST improves the quality of that skin without adding volume. It is not an under-eye filler. It is about making that skin stronger, more hydrated and less crepey.
Areas Commonly Treated With NEWEST
Skin quality improvement across multiple zones
Face
Hydration, glow, elasticity and general skin quality improvement
Neck
Thin, crepey or less elastic skin that needs structural support
Under-Eyes
Improving skin quality in the delicate under-eye area without filler volume
Décolletage
Crepey or sun-damaged looking skin on the chest
Hands
Ageing or thinning skin where filler is not appropriate
NEWEST vs Filler vs Skin Booster
These three get confused a lot. Here is the honest difference:
NEWEST
dehydrated skin, dull or flat complexion, reduced elasticity, early ageing, crepey skin, fragile skin texture, or wanting natural improvement without structural change
Improves skin quality
Filler
lip volume, cheek projection, chin definition or any structural change to your face
Adds volume and creates shape
Simple Skin Booster
mild hydration, early-stage maintenance, or a lighter treatment approach without the regenerative component
Adds basic hydration
NEWEST works gradually on skin quality rather than adding volume. Patients needing texture refinement and scar reduction can explore acne scar treatment Malaysia. Those with uneven pigmentation alongside dehydration may pair NEWEST with melasma treatment Malaysia.
The NEWEST Procedure at Nexus Clinic KL
Step by step — regenerative skin hydration
Full Skin Assessment
The doctor reviews your skin hydration, elasticity, texture, radiance and treatment history. Not every patient who asks for NEWEST is the right candidate for it, and this is where that gets sorted out properly.
Personalised Treatment Plan
The doctor decides whether NEWEST is appropriate and how many sessions make sense for your skin condition. If something else would work better for your concern, that will come up here before anything is booked.
Injection Session
NEWEST is injected using an intradermal skin-booster technique across the planned areas. Each session takes between 20 and 45 minutes depending on the areas being treated.
Early Recovery
Small raised bumps at the injection points are normal and look similar to mild mosquito bites. Mild redness and some slight swelling can happen. These settle within 24 to 48 hours.
Gradual Improvement
Hydration and glow tend to show earlier, usually within the first two weeks. Elasticity, texture and collagen-related improvements build over the full treatment course and continue developing for several weeks after.
Maintenance
After the initial course, maintenance sessions every six months keep the results sustained. How often depends on age, skin condition and how the skin responds.
20-45 minute sessions at Nexus Clinic KL
NEWEST Cost in Malaysia 2026
For context, polynucleotide skin boosters in Malaysia generally range from RM 1,500 to RM 3,500 per session depending on the product, clinic and doctor. NEWEST at Nexus sits well below that range without compromising on product quality. It is a genuine Mastelli-manufactured treatment made in Italy.For context, polynucleotide skin boosters in Malaysia generally range from RM 1,500 to RM 3,500 per session depending on the product, clinic and doctor. NEWEST at Nexus sits well below that range without compromising on product quality. It is a genuine Mastelli-manufactured treatment made in Italy.
| Treatment | Product / Option | Parts / Areas | Units / Session / Duration | Normal Price RM | Selling Price RM | Standard Package |
|---|---|---|---|---|---|---|
| Newest | Newest 4ml | Face / Neck | Per session | RM 500 | RM 500 | Package Price i.e. buy 4, get 1 free |
Treatment
Newest
Product / Option
Newest 4ml
Parts / Areas
Face / Neck
Units / Session / Duration
Per session
Normal Price RM
RM 500
Selling Price RM
RM 500
Standard Package
Package Price i.e. buy 4, get 1 free
Factors That Affect Your NEWEST Price
- •Number of sessions needed based on your skin condition
- •Areas being treated: face only is different from adding neck, under-eyes, hands or décolletage
- •Amount of product used and complexity of the injection plan
- •Whether NEWEST is being used alone or as part of a broader treatment plan
- •Injector experience and clinic setting
NEWEST requires 3 to 4 sessions for optimal results. Patients seeking maintenance can add laser hair removal Malaysia for facial grooming. Those with persistent redness or sensitivity may also review rosacea treatment Malaysia alongside their skin booster plan.
Benefits of NEWEST
- Improves skin hydration from within the dermis, not just on the surface
- Supports fibroblast activity, which helps the skin produce collagen and elastin again
- Restores skin elasticity and rigidity over the treatment course
- Improves skin texture, density and how the skin reflects light
- Softens fine lines caused by collagen loss and skin thinning
- Works on delicate areas like the under-eyes, neck and hands where filler is not appropriate
- Results look natural because the skin is improving its own quality
- Low downtime for most patients
- Suitable for all skin types including Asian skin
Limitations of NEWEST
- ⚠️It is not a contouring filler and will not reshape the lips, chin, cheeks or jawline
- ⚠️Results build gradually, especially for collagen and elastin improvement
- ⚠️A course of 3 to 4 sessions is needed for proper results, one session is not enough
- ⚠️Maintenance is required to sustain results long-term
- ⚠️It will not lift skin that has significantly sagged
- ⚠️Not suitable during pregnancy or breastfeeding
If the real concern is volume loss or structural change, NEWEST alone will not give you the result you are expecting. The doctor at Nexus Clinic will tell you this clearly at consultation.
NEWEST Side Effects and Aftercare
Temporary, rare and usually mild
Common Temporary Effects
- Small raised bumps at the injection points, similar to mosquito bites
- Mild redness around the treated area
- Slight swelling that settles within a day or two
- Light bruising in some patients
- Temporary tenderness at injection sites
Rare Risks
- ⚠️Infection
- ⚠️Prolonged lumps at injection points
- ⚠️Allergic reaction
- ⚠️Vascular complications, which are uncommon but need proper medical management if they occur
These are uncommon. A proper doctor assessment and clinical setting significantly reduce these risks.
NEWEST Aftercare Instructions
The improvement builds over weeks, not days, especially for the collagen and elastin changes. Early judgement is not fair to the treatment.
Award-Winning Injectors
at Nexus Clinic KL
You came here wanting to look like yourself, just refreshed. At Nexus Clinic KL, our award-winning aesthetic doctors specialise in results that are noticed but never obvious. Better skin, natural balance, and a face that simply looks well-rested.
Every treatment plan is personalised to your skin concerns, facial features and aesthetic goals. Using advanced regenerative treatments and precise injection techniques, we help you achieve facial harmony without the overdone look.
Frequently Asked Questions
NEWEST is a polynucleotide injectable skin booster made by Mastelli that supports skin hydration, elasticity, fibroblast activity, collagen stimulation and overall skin rejuvenation. It combines PN-HPT with hyaluronic acid and mannitol.
No. NEWEST improves skin quality from within. It does not add volume, reshape the face or create structural change. It is a regenerative skin booster, not a contouring filler.
Both are made by Mastelli using PN-HPT technology. Plinest is pure polynucleotide for deep regenerative repair. NEWEST adds hyaluronic acid and mannitol, making it better suited for patients who want both repair and visible hydration in the same session.
A course of 3 to 4 sessions spaced 2 to 4 weeks apart is the standard. The exact plan depends on your skin condition and the areas being treated.
Results from a completed course typically last 6 to 12 months depending on age, lifestyle and how the skin responds. Maintenance every 6 months keeps the improvement sustained.
Mild stinging at each injection point. The whole session is done in under 45 minutes and most patients find it very manageable. Numbing cream is available if needed.
Yes. These are among the most common treatment areas. The polynucleotide formula works well in delicate, thin skin areas where filler is not suitable.
No. They are different products with different formulas and different mechanisms. There is some overlap in the broader skin-rejuvenation space but they are not interchangeable.
Very little. Small bumps, mild redness and light bruising can happen on the day but these are temporary. Most patients are back to their normal routine the same day.
Patients who are pregnant, breastfeeding, or have an active skin infection in the treatment area. Suitability is always confirmed by the doctor at consultation.
Book NEWEST in Kuala Lumpur at Nexus Clinic KL
If your skin looks dry, dull, weaker or less elastic than before, NEWEST may be the treatment that helps bring back a fresher, more hydrated and healthier-looking version of your skin from within.
No heavy filler look. No fake change. No unnecessary volume. Just better skin quality, stronger hydration support and a more refined result that still looks like you.
Limited slots available this week | Located at Wisma UOA II, Jalan Pinang, KLCC — Serving Malaysia since 2001